Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.65 |
| ▸ | PDE4A | P27815 | 18/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 18/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 18/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7418766 | 1.00 | PDE4B (0.65) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL7861040 | 1.00 | PDE4B (0.65) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL7855470 | 0.92 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7855467 | 0.92 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7863406 | 0.91 | PDE4B (0.66) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7417971 | 0.91 | PDE4B (0.74) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7416970 | 0.91 | PDE4B (0.66) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7416969 | 0.91 | PDE4B (0.66) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7417973 | 0.91 | PDE4B (0.74) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7862312 | 0.91 | PDE4B (0.74) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300372-B1 | USED IN THERAPY OF ALLERGIC AND INFLAMMATORY DISEASES AND FOR INHIBITING THE PRODUCTION OF TUMOR NECROSIS FACTOR (TNF) | SMITHKLINE BEECHAM CORPORATION | 2001-10-09 | — | — | US | disclosed |