Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL859085 | 0.87 | STK4 (0.31) | PIK3CAPIK3CDPIK3CGKIT | |
| SCHEMBL856623 | 0.85 | PIK3CA (0.36) | PIK3CAPIK3CDPIK3CGPIK3CBUSP2 | |
| SCHEMBL3806243 | 0.85 | PIK3CA (0.44) | PIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL859260 | 0.85 | PIK3CA (0.35) | PIK3CAPIK3CDPIK3CGPIK3CBUSP2 | |
| SCHEMBL3750629 | 0.85 | PIK3CA (0.34) | PIK3CAPIK3CDPIK3CGPIK3CBUSP2 | |
| SCHEMBL3760570 | 0.84 | PIK3CA (0.37) | PIK3CAPIK3CGLMNA | |
| SCHEMBL3756904 | 0.84 | PIK3CA (0.34) | PIK3CAPIK3CDPIK3CGPIK3CBUSP2 | |
| SCHEMBL3751018 | 0.84 | PIK3CA (0.46) | PIK3CAUSP2ALDH1A1LMNACYP1A2 | |
| SCHEMBL3758825 | 0.84 | PDE10A (0.41) | PIK3CAPIK3CDPIK3CGPIK3CBKIT | |
| SCHEMBL3762381 | 0.84 | PIK3CA (0.34) | PIK3CAPIK3CDPIK3CGPIK3CBUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010135524-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |