Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 12/20 | 0.70 |
| ▸ | FNTA | P49354 | 1/20 | 0.52 |
| ▸ | FNTB | P49356 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7652633 | 1.00 | HRAS (0.70) | HRASFNTAFNTBHDAC8ITGB3 | |
| SCHEMBL14193151 | 0.95 | HRAS (0.77) | HRASFNTAFNTBITGB3ITGA2B | |
| SCHEMBL7655158 | 0.95 | HRAS (0.70) | HRASFNTAFNTB | |
| SCHEMBL8526242 | 0.95 | HRAS (0.70) | HRASFNTAFNTB | |
| SCHEMBL7867938 | 0.94 | HRAS (0.68) | HRASFNTAFNTB | |
| SCHEMBL7647710 | 0.94 | HRAS (0.68) | HRASFNTAFNTB | |
| SCHEMBL7655449 | 0.93 | HRAS (0.62) | HRASFNTAFNTBMEN1KMT2A | |
| SCHEMBL7649521 | 0.93 | HRAS (0.68) | HRASFNTAFNTB | |
| SCHEMBL7651089 | 0.92 | HRAS (0.67) | HRASFNTAFNTB | |
| SCHEMBL7651708 | 0.92 | HRAS (0.67) | HRASFNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300501-B1 | Histidine-(N-benzyl glycinamide) inhibitors of protein farnesyl transferase | WARNER-LAMBERT COMPANY | 2001-10-09 | — | — | US | claimed |