Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 4/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA7 | P43166 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | TACR1 | P25103 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4545488 | 1.00 | TSHR (0.52) | TSHRKMT2ACA1CA2CA7 | |
| SCHEMBL13002270 | 1.00 | TSHR (0.52) | TSHRKMT2ACA1CA2CA7 | |
| SCHEMBL14453899 | 0.92 | TSHR (0.61) | TSHRKMT2ACA1CA2CA7 | |
| SCHEMBL7604498 | 0.83 | AGXT (0.44) | KMT2ACA1CA2CA9TACR1 | |
| SCHEMBL13246484 | 0.83 | TSHR (0.50) | TSHRKMT2ACA1CA2CA7 | |
| SCHEMBL10052366 | 0.82 | TSHR (0.54) | TSHRKMT2ACA1CA2CA7 | |
| SCHEMBL12519871 | 0.82 | TSHR (0.54) | TSHRKMT2ACA1CA2CA7 | |
| SCHEMBL12519869 | 0.82 | TSHR (0.54) | TSHRKMT2ACA1CA2CA7 | |
| SCHEMBL13003073 | 0.82 | TSHR (0.54) | TSHRKMT2ACA1CA2CA7 | |
| SCHEMBL1013889 | 0.81 | IDO1 (0.42) | KMT2ACA1CA2TACR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |