Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | LSS | P48449 | 6/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 9/20 | 0.45 |
| ▸ | KDM5A | P29375 | 7/20 | 0.45 |
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.44 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.42 |
| ▸ | KDM4A | O75164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7866824 | 0.94 | ABCC4 (0.45) | ABCC4MAPTLSSKDM4CKDM5A | |
| SCHEMBL3207997 | 0.86 | LSS (0.39) | ABCC4MAPTLSSKDM4CKDM5A | |
| Hydrochloric Acid SCHEMBL27738298 | 0.84 | MEN1 (0.42) | ABCC4MAPTLSSKDM4CKDM5A | |
| Adipic Acid SCHEMBL27616118 | 0.82 | ABCC4 (0.54) | ABCC4MAPTLMNATSHRNFKB1 | |
| SCHEMBL11774570 | 0.79 | TSHR (0.60) | KDM4CKDM5AKDM5CKDM5BPHF8 | |
| SCHEMBL7858923 | 0.78 | TSHR (0.46) | LSSKDM4CKDM5AKDM5CKDM5B | |
| Butyric Acid SCHEMBL28800929 | 0.76 | FFAR3 (0.54) | ABCC4MAPTKDM5CPHF8TSHR | |
| SCHEMBL25785017 | 0.76 | LSS (0.38) | LSS | |
| SCHEMBL4484944 | 0.75 | LSS (0.40) | LSS | |
| SCHEMBL4484949 | 0.75 | LSS (0.40) | LSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1085667-C | Substituted tetracyclic azepine derivatives having affinity for 5-HT2 receptors | JANSSEN PHARMACEUTICA NV (BE) | 2002-05-29 | — | — | CN | disclosed |
| EP-0789701-B1 | SUBSTITUTED TETRACYCLIC AZEPINE DERIVATIVES WHICH HAVE AFFINITY FOR 5-HT2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2001-02-07 | — | — | EP | disclosed |
| CN-1162313-A | Substituted tetracyclic azepine derivatives having affinity for 5-HT2 receptors | JANSSEN PHARMACEUTICA NV (BE) | 1997-10-15 | — | — | CN | disclosed |
| EP-0789701-A1 | SUBSTITUTED TETRACYCLIC AZEPINE DERIVATIVES WHICH HAVE AFFINITY FOR 5-HT2 RECEPTORS | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-08-20 | — | — | EP | disclosed |
| US-5552399-A | TREATMENT OR PREVENTION OF CENTRAL NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS, GASTROINTESTINAL DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-09-03 | — | — | US | disclosed |
| WO-1996014320-A1 | SUBSTITUTED TETRACYCLIC AZEPINE DERIVATIVES WHICH HAVE AFFINITY FOR 5-HT2 RECEPTORS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-05-17 | — | — | WO | disclosed |