SCHEMBL7864634

SCHEMBL7864634

COc1cnc(OC)n2nc(NS(=O)(=O)c3c(OCCF)cccc3C(F)(F)F)nc12

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC22A12 Q96S37 3/20 0.37
LRRK2 Q5S007 1/20 0.37
CCR4 P51679 1/20 0.34
SCN9A Q15858 2/20 0.33
MAPK10 P53779 1/20 0.33
AXL P30530 2/20 0.33
TSHR P16473 3/20 0.33
ALDH1A1 P00352 2/20 0.33
CYP1A2 P05177 2/20 0.33
CYP3A4 P08684 2/20 0.33
CYP2D6 P10635 2/20 0.33
CYP2C19 P33261 2/20 0.33
KDM4E B2RXH2 2/20 0.33
NPSR1 Q6W5P4 2/20 0.33
ALOX15 P16050 2/20 0.33
MAPK1 P28482 2/20 0.33
HSD17B10 Q99714 2/20 0.33
KMT2A Q03164 2/20 0.33
MEN1 O00255 1/20 0.33
HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7864594 0.92 SLC22A12 (0.37) SLC22A12LRRK2CCR4SCN9AMAPK10
SCHEMBL7865966 0.90 SLC22A12 (0.34) SLC22A12CCR4SCN9AMAPK10TSHR
Penoxsulam SCHEMBL116968 0.89 PSEN1 (0.35) SLC22A12CCR4SCN9AMAPK10TSHR
SCHEMBL6630344 0.88 CCR4 (0.37) SLC22A12LRRK2CCR4SCN9AAXL
Penoxsulam SCHEMBL22587372 0.88 PSEN1 (0.34) SLC22A12CCR4SCN9AMAPK10TSHR
SCHEMBL17864073 0.87 SLC22A12 (0.34) SLC22A12CCR4SCN9AMAPK10TSHR
SCHEMBL7864603 0.84 CCR4 (0.39) SLC22A12LRRK2CCR4SCN9AMAPK10
SCHEMBL7859430 0.84 KAT7 (0.38) ALDH1A1
SCHEMBL17864141 0.82 EDNRA (0.34) SLC22A12CCR4SCN9AMAPK10TSHR
SCHEMBL16359710 0.81 SLC22A12 (0.41) SLC22A12CCR4SCN9AAXLTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0877745-B1 N-( 1,2,4] TRIAZOLOAZINYL)BENZENESULFONAMIDE AND PYRIDINESULFONAMIDE COMPOUNDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2001-07-25 EP claimed
US-6303814-B1 N-[1,2,4]triazoloazinyl) benzenesulfonamide and pyridinesulfonamide compounds and their use as herbicides DOW AGROSCIENCES LLC 2001-10-16 US disclosed
EP-0877745-B1 N-( 1,2,4] TRIAZOLOAZINYL)BENZENESULFONAMIDE AND PYRIDINESULFONAMIDE COMPOUNDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2001-07-25 EP disclosed
US-6130335-A N-([1,2,4]triazoloazinyl) benzenesulfonamide and pyridinesulfonamide compounds and their use as herbicides DOW AGROSCIENCES LLC (US) 2000-10-10 US disclosed
US-6005108-A POST-EMERGENCE TOTAL VEGETATION CONTROL OR SELECTIVE CONTROL OF WEEDS IN WHEAT, RICE AND OIL-SEED RAPE CROPS JOHNSON TIMOTHY C (US) 1999-12-21 US disclosed
US-5965490-A NOVEL COMPOUNDS WITH IMPROVED SELECTIVITY TO VALUABLE CROPS AND IMPROVED TOXICOLOGICAL AND ENVIRONMENTAL ATTRIBUTES; APPLYING TO CONTROL WEEDS BY EITHER PREEMERGENCE OR POSTEMERGENCE APPLICATION DOW AGROSCIENCES LLC (US) 1999-10-12 US disclosed
US-5858924-A N-( 1, 2, 4! triazoloazinyl) benzenesulfonamide and pyridinesulfonamide compounds and their use as herbicides DOW AGROSCIENCES LLC (US) 1999-01-12 US disclosed
EP-0877745-A2 N-( 1,2,4] TRIAZOLOAZINYL)BENZENESULFONAMIDE AND PYRIDINESULFONAMIDE COMPOUNDS AND THEIR USE AS HERBICIDES Dow Agrosciences LLC (US) 1998-11-18 EP disclosed
WO-1998013367-A1 N-([1,2,4] TRIAZOLOAZINYL)BENZENESULFONAMIDE AND PYRIDINESULFONAMIDE COMPOUNDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 1998-04-02 WO disclosed