Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.80 |
| ▸ | RET | P07949 | 7/20 | 0.80 |
| ▸ | KIF5B | P33176 | 5/20 | 0.80 |
| ▸ | EGFR | P00533 | 10/20 | 0.69 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.62 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.62 |
| ▸ | BRAF | P15056 | 2/20 | 0.62 |
| ▸ | JAK3 | P52333 | 2/20 | 0.62 |
| ▸ | GAK | O14976 | 1/20 | 0.62 |
| ▸ | STK10 | O94804 | 1/20 | 0.62 |
| ▸ | FLT3 | P36888 | 1/20 | 0.62 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.62 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.62 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.62 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.62 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.62 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.62 |
| ▸ | FLT1 | P17948 | 1/20 | 0.62 |
| ▸ | CDK2 | P24941 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7454466 | 0.91 | KDR (0.78) | KDRRETKIF5BEGFRRIPK2 | |
| Hydrochloric Acid SCHEMBL7455631 | 0.90 | KDR (0.77) | KDRRETKIF5BEGFRRIPK2 | |
| SCHEMBL7459697 | 0.90 | KDR (0.74) | KDRRETKIF5BEGFRRIPK2 | |
| SCHEMBL5651286 | 0.89 | KDR (1.00) | KDRRETKIF5BEGFRRIPK2 | |
| SCHEMBL8707744 | 0.88 | EGFR (0.70) | KDRRETKIF5BEGFRRIPK2 | |
| Hydrochloric Acid SCHEMBL7859467 | 0.88 | KDR (0.98) | KDRRETKIF5BEGFRRIPK2 | |
| SCHEMBL7455454 | 0.88 | EGFR (0.79) | KDRRETKIF5BEGFRRIPK2 | |
| Hydrochloric Acid SCHEMBL7455938 | 0.87 | EGFR (0.77) | KDRRETKIF5BEGFRRIPK2 | |
| Hydrochloric Acid SCHEMBL8809576 | 0.87 | EGFR (0.76) | KDRRETKIF5BEGFRRIPK2 | |
| SCHEMBL8203666 | 0.87 | KDR (0.74) | KDRRETKIF5BEGFRRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885198-B1 | 4-ANILINOQUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-12-19 | — | — | EP | disclosed |
| US-6291455-B1 | PRODUCING AN ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY REDUCING EFFECT | ZENECA LIMITED (GB) | 2001-09-18 | — | — | US | disclosed |
| EP-0885198-A1 | 4-ANILINOQUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032856-A1 | 4-ANILINOQUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-09-12 | — | — | WO | disclosed |