Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 11/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7645386 | 0.99 | TRPV1 (0.60) | TRPV1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7644642 | 0.86 | TRPV1 (0.52) | TRPV1CYP3A4ALOX15 | |
| SCHEMBL7649156 | 0.85 | TRPV1 (0.54) | TRPV1CYP3A4ALOX15 | |
| SCHEMBL7644756 | 0.84 | TRPV1 (0.67) | TRPV1 | |
| SCHEMBL7644763 | 0.84 | TRPV1 (0.67) | TRPV1 | |
| SCHEMBL7644672 | 0.80 | TRPV1 (0.51) | TRPV1 | |
| SCHEMBL7648455 | 0.79 | TRPV1 (0.64) | TRPV1 | |
| SCHEMBL7644748 | 0.78 | TRPV1 (0.48) | TRPV1 | |
| SCHEMBL7646868 | 0.76 | TRPV1 (0.79) | TRPV1 | |
| SCHEMBL7643950 | 0.76 | TRPV1 (0.66) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1154989-A1 | VANILLOID ANALOGUES CONTAINING RESINIFERATOXIN PHARMACOPHORES AS POTENT VANILLOID RECEPTOR AGONISTS AND ANALGESICS, COMPOSITIONS AND USES THEREOF | PACIFIC CORPORATION (KR) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000050387-A1 | VANILLOID ANALOGUES CONTAINING RESINIFERATOXIN PHARMACOPHORES AS POTENT VANILLOID RECEPTOR AGONISTS AND ANALGESICS, COMPOSITIONS AND USES THEREOF | PACIFIC CORPORATION (KR) | 2000-08-31 | — | — | WO | disclosed |