Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | P2RX1 | P51575 | 4/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7866260 | 0.90 | TLR8 (0.51) | TLR8KDM4ETDP1POLBNPSR1 | |
| SCHEMBL7777742 | 0.90 | TDP1 (0.58) | KDM4ETDP1POLBNPSR1MEN1 | |
| SCHEMBL134353 | 0.78 | P2RX1 (0.60) | P2RX1P2RX7MEN1KMT2AP2RX4 | |
| SCHEMBL6815985 | 0.74 | TLR8 (0.61) | TLR8TDP1NPSR1P2RX1P2RX7 | |
| SCHEMBL6819187 | 0.74 | TLR8 (0.71) | TLR8TDP1P2RX1P2RX7MEN1 | |
| SCHEMBL6816653 | 0.72 | MYC (0.67) | TLR8TDP1NPSR1P2RX1P2RX7 | |
| SCHEMBL6811322 | 0.72 | TLR8 (0.68) | TLR8KDM4ETDP1P2RX1P2RX7 | |
| SCHEMBL6816655 | 0.71 | TLR8 (0.60) | TLR8TDP1P2RX1P2RX7MEN1 | |
| SCHEMBL6819257 | 0.69 | TLR8 (0.55) | TLR8TDP1NPSR1P2RX1P2RX7 | |
| SCHEMBL6819505 | 0.69 | TLR8 (0.53) | TLR8KDM4ETDP1P2RX1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140913-A1 | THIOUREA INHIBITORS OF HERPES VIRUSES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000034269-A1 | THIOUREA INHIBITORS OF HERPES VIRUSES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |