Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 3/20 | 0.55 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | CDK7 | P50613 | 1/20 | 0.55 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.55 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.55 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.55 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.55 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.55 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.55 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.55 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.36 |
| ▸ | STK17B | O94768 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10079716 | 0.86 | CDK7 (0.74) | CDK5DYRK3CDK1CDK2GSK3B | |
| SCHEMBL477813 | 0.85 | CDK7 (0.76) | CDK5DYRK3CDK1CDK2GSK3B | |
| SCHEMBL7865392 | 0.76 | CDK5 (0.45) | CDK5DYRK3CDK1CDK2GSK3B | |
| SCHEMBL4069900 | 0.73 | CDK1 (0.74) | CDK5DYRK3CDK1CDK2GSK3B | |
| Hydrochloric Acid SCHEMBL4066580 | 0.73 | CDK1 (0.72) | CDK5DYRK3CDK1CDK2GSK3B | |
| Hydrochloric Acid SCHEMBL3202835 | 0.72 | CDK7 (0.68) | CDK5DYRK3CDK1CDK2GSK3B | |
| Azd-1080 SCHEMBL29361806 | 0.71 | CDK7 (1.00) | CDK5DYRK3CDK1CDK2GSK3B | |
| Azd-1080 SCHEMBL30298327 | 0.71 | CDK7 (1.00) | CDK5DYRK3CDK1CDK2GSK3B | |
| SCHEMBL4062133 | 0.71 | CDK2 (0.70) | CDK5DYRK3CDK1CDK2GSK3B | |
| SCHEMBL12393826 | 0.71 | CDK7 (0.70) | CDK5DYRK3CDK1CDK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010109005-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE-3 INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2010-09-30 | — | — | WO | disclosed |