Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.80 |
| ▸ | FLT1 | P17948 | 9/20 | 0.80 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.80 |
| ▸ | EGFR | P00533 | 8/20 | 0.78 |
| ▸ | RET | P07949 | 5/20 | 0.78 |
| ▸ | KIF5B | P33176 | 5/20 | 0.78 |
| ▸ | FLT4 | P35916 | 4/20 | 0.76 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.76 |
| ▸ | RAF1 | P04049 | 1/20 | 0.68 |
| ▸ | BRAF | P15056 | 1/20 | 0.68 |
| ▸ | SRC | P12931 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7870586 | 0.99 | KDR (0.78) | KDRFLT1FGFR1EGFRRET | |
| SCHEMBL7865988 | 0.91 | KDR (0.80) | KDRFLT1FGFR1EGFRRET | |
| SCHEMBL2055589 | 0.91 | RAF1 (0.76) | KDRFLT1FGFR1EGFRRET | |
| SCHEMBL21557441 | 0.91 | KDR (0.71) | KDRFLT1FGFR1EGFRRET | |
| Hydrochloric Acid SCHEMBL7867718 | 0.90 | KDR (0.78) | KDRFLT1FGFR1EGFRRET | |
| Hydrochloric Acid SCHEMBL2139091 | 0.89 | EGFR (0.67) | KDRFLT1FGFR1EGFRRET | |
| SCHEMBL19220777 | 0.88 | RET (0.67) | KDRFLT1FGFR1EGFRRET | |
| SCHEMBL5864525 | 0.88 | KDR (1.00) | KDRFLT1FGFR1EGFRRET | |
| SCHEMBL27109251 | 0.87 | KDR (1.00) | KDRFLT1FGFR1EGFRRET | |
| SCHEMBL19220775 | 0.87 | RET (0.64) | KDRFLT1FGFR1EGFRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885198-B1 | 4-ANILINOQUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-12-19 | — | — | EP | disclosed |
| US-6291455-B1 | PRODUCING AN ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY REDUCING EFFECT | ZENECA LIMITED (GB) | 2001-09-18 | — | — | US | disclosed |
| EP-0885198-A1 | 4-ANILINOQUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032856-A1 | 4-ANILINOQUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-09-12 | — | — | WO | disclosed |