Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.56 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3755076 | 0.94 | PIK3CA (0.55) | PIK3CAPRKDCGPR142 | |
| SCHEMBL3760844 | 0.92 | PIK3CA (0.57) | PIK3CAPRKDCGPR142 | |
| SCHEMBL3758904 | 0.88 | PIK3CA (0.59) | PIK3CAPRKDCCREBBPGPR142 | |
| SCHEMBL3754020 | 0.86 | PIK3CA (0.57) | PIK3CAPRKDCGPR142 | |
| SCHEMBL3756240 | 0.86 | PIK3CA (0.63) | PIK3CA | |
| SCHEMBL3755678 | 0.85 | PIK3CA (0.65) | PIK3CAPRKDC | |
| SCHEMBL3757004 | 0.85 | PIK3CA (0.65) | PIK3CAPRKDCCREBBP | |
| SCHEMBL3749446 | 0.85 | PIK3CA (0.58) | PIK3CAPRKDC | |
| SCHEMBL3758220 | 0.85 | PIK3CA (0.60) | PIK3CAPRKDCGPR142 | |
| SCHEMBL3755858 | 0.85 | PIK3CA (0.61) | PIK3CAPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118208-A1 | BENZOXAZEPIN-4- (5H) -YL DERIVATIVES AND THEIR USE TO TREAT CANCER | EXELIXIS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |