Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.98 |
| ▸ | FGFR1 | P11362 | 15/20 | 0.98 |
| ▸ | FLT1 | P17948 | 15/20 | 0.98 |
| ▸ | EGFR | P00533 | 14/20 | 0.98 |
| ▸ | FLT4 | P35916 | 12/20 | 0.98 |
| ▸ | AURKA | O14965 | 3/20 | 0.77 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.77 |
| ▸ | TEK | Q02763 | 3/20 | 0.77 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.77 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.71 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7864665 | 0.99 | KDR (1.00) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL7864669 | 0.96 | KDR (1.00) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL1467998 | 0.94 | KDR (0.90) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL1468087 | 0.94 | FGFR1 (0.98) | KDRFGFR1FLT1EGFRFLT4 | |
| Hydrochloric Acid SCHEMBL1468148 | 0.93 | KDR (0.89) | KDRFGFR1FLT1EGFRFLT4 | |
| Hydrochloric Acid SCHEMBL27218199 | 0.93 | FGFR1 (1.00) | KDRFGFR1FLT1EGFRFLT4 | |
| Hydrochloric Acid SCHEMBL1467744 | 0.92 | FGFR1 (0.98) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL7857964 | 0.92 | KDR (1.00) | KDRFGFR1FLT1EGFRFLT4 | |
| Hydrochloric Acid SCHEMBL7870593 | 0.91 | KDR (0.98) | KDRFGFR1FLT1EGFRFLT4 | |
| Hydrochloric Acid SCHEMBL27218174 | 0.90 | EGFR (1.00) | KDRFGFR1FLT1EGFRFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885198-B1 | 4-ANILINOQUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-12-19 | — | — | EP | disclosed |
| US-6291455-B1 | PRODUCING AN ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY REDUCING EFFECT | ZENECA LIMITED (GB) | 2001-09-18 | — | — | US | disclosed |