Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.76 |
| ▸ | HDAC3 | O15379 | 16/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 16/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 16/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 16/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 16/20 | 0.49 |
| ▸ | ECE1 | P42892 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL724051 | 0.91 | EGFR (0.76) | EGFRHDAC3HDAC1HDAC7HDAC8 | |
| SCHEMBL722468 | 0.91 | EGFR (0.76) | EGFRHDAC3HDAC1HDAC7HDAC8 | |
| SCHEMBL722467 | 0.91 | EGFR (0.76) | EGFRHDAC3HDAC1HDAC7HDAC8 | |
| SCHEMBL771177 | 0.89 | EGFR (0.74) | EGFRHDAC3HDAC1HDAC7HDAC8 | |
| SCHEMBL770133 | 0.89 | EGFR (0.74) | EGFRHDAC3HDAC1HDAC7HDAC8 | |
| SCHEMBL770132 | 0.89 | EGFR (0.74) | EGFRHDAC3HDAC1HDAC7HDAC8 | |
| SCHEMBL724061 | 0.89 | EGFR (0.74) | EGFRHDAC3HDAC1HDAC7HDAC8 | |
| SCHEMBL724062 | 0.89 | EGFR (0.74) | EGFRHDAC3HDAC1HDAC7HDAC8 | |
| SCHEMBL770521 | 0.89 | EGFR (0.74) | EGFRHDAC3HDAC1HDAC7HDAC8 | |
| SCHEMBL786635 | 0.86 | EGFR (0.70) | EGFRHDAC3HDAC1HDAC7HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170226086-A1 | COMPOUNDS FOR TREATMENT OF CANCER | GTx. Inc. (US) | 2017-08-10 | — | — | US | disclosed |
| US-9447049-B2 | Compounds for treatment of cancer | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2016-09-20 | — | — | US | disclosed |
| US-9334242-B2 | Compounds for treatment of cancer | GTX, INC. (US) | 2016-05-10 | — | — | US | disclosed |
| US-8822513-B2 | Compounds for treatment of cancer | GTX, INC. (US) | 2014-09-02 | — | — | US | disclosed |
| US-20130197049-A1 | COMPOUNDS FOR TREATMENT OF CANCER | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2013-08-01 | — | — | US | disclosed |
| US-20120071524-A1 | COMPOUNDS FOR TREATMENT OF CANCER | ONCTERNAL THERAPEUTICS, INC | 2012-03-22 | — | — | US | disclosed |
| US-20110257196-A1 | COMPOUNDS FOR TREATMENT OF CANCER | ONCTERNAL THERAPEUTICS, INC | 2011-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071524-A1 | COMPOUNDS FOR TREATMENT OF CANCER | KLK3, BRDT, ACP3 | EGFR 964/4885HDAC3 39/4885HDAC1 19/4885 |
| US-20130197049-A1 | COMPOUNDS FOR TREATMENT OF CANCER | KLK3, BRDT, ACP3 | EGFR 964/4885HDAC3 39/4885HDAC1 19/4885 |
| US-20170226086-A1 | COMPOUNDS FOR TREATMENT OF CANCER | KLK3, BRDT, ACP3 | EGFR 964/4885HDAC3 39/4885HDAC1 19/4885 |
| US-20110257196-A1 | COMPOUNDS FOR TREATMENT OF CANCER | KLK3, BRDT, ACP3 | EGFR 964/4885HDAC3 39/4885HDAC1 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.