SCHEMBL7868231

SCHEMBL7868231

NC(=O)c1ccc2nc(S)[nH]c2c1

nearest known ligand 0.60

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CHEK2 O96017 19/20 0.60
PKN1 Q16512 1/20 0.58
PKN2 Q16513 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16134556 0.87 CHEK2 (0.46) CHEK2PKN1PKN2
SCHEMBL766093 0.85 HSP90AA1 (0.66) CHEK2
SCHEMBL17821410 0.83 HSP90AA1 (0.51) CHEK2PKN1PKN2
SCHEMBL7868225 0.83 HSP90AA1 (0.47) CHEK2PKN1PKN2
SCHEMBL29242251 0.83 HSP90AA1 (0.64) CHEK2
SCHEMBL12685844 0.81 ABL1 (0.68) CHEK2PKN1PKN2
SCHEMBL3416768 0.81 CHEK2 (0.61) CHEK2PKN1PKN2
SCHEMBL7428472 0.80 HSP90AA1 (0.73) CHEK2PKN1PKN2
SCHEMBL9304016 0.80 CHEK2 (0.63) CHEK2PKN1PKN2
SCHEMBL6217370 0.80 HTT (0.64) PKN1PKN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6329135-B1 LIGHT INSENSITIVE ORGANIC SILVER SALT ON A SUPPORT KONICA CORPORATION (JP) 2001-12-11 US disclosed
EP-1058151-A1 Silver halide photothermographic material KONICA CORPORATION (JP) 2000-12-06 EP disclosed
US-5922529-A MATERIAL HAVING PHOTOSENSITIVE LAYER CONTAINING MERCAPTAN COMPOUND AND MEROCYANINE DYE; IMPROVED SHARPNESS, SENSITIVITY, AGING STABILITY FUJI PHOTO FILM CO., LTD. (JP) 1999-07-13 US disclosed