Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 20/20 | 0.78 |
| ▸ | TP53 | P04637 | 1/20 | 0.78 |
| ▸ | MDM4 | O15151 | 9/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL222321 | 1.00 | MDM2 (0.78) | MDM2TP53MDM4 | |
| SCHEMBL222322 | 1.00 | MDM2 (0.78) | MDM2TP53MDM4 | |
| SCHEMBL222265 | 0.94 | MDM2 (0.70) | MDM2TP53MDM4 | |
| SCHEMBL222575 | 0.94 | MDM2 (0.70) | MDM2TP53MDM4 | |
| SCHEMBL222576 | 0.94 | MDM2 (0.70) | MDM2TP53MDM4 | |
| SCHEMBL222264 | 0.94 | MDM2 (0.70) | MDM2TP53MDM4 | |
| SCHEMBL222411 | 0.91 | MDM2 (0.79) | MDM2TP53MDM4 | |
| SCHEMBL222410 | 0.91 | MDM2 (0.79) | MDM2TP53MDM4 | |
| SCHEMBL221308 | 0.90 | MDM2 (0.76) | MDM2TP53MDM4 | |
| SCHEMBL221309 | 0.90 | MDM2 (0.76) | MDM2TP53MDM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038307-A1 | SPIRO SUBSTITUTED PYRROLO[1,2-C]IMIDAZOLE DERIVATIVES USEFUL AS MDM2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-29 | — | — | WO | disclosed |
| US-20120071499-A1 | Substituted Spiro[3H-Indole-3,6'(5'H)-[1H]Pyrrolo[1,2c]Imidazole-1',2(1H,2'H)-diones | CHU XIN-JIE (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071499-A1 | Substituted Spiro[3H-Indole-3,6'(5'H)-[1H]Pyrrolo[1,2c]Imidazole-1',2(1H,2'H)-diones | IDO1, IDH3A, H1-3 | MDM2 230/4885TP53 40/4885MDM4 2821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.