SCHEMBL7868274

SCHEMBL7868274

C=CCOCC(CO)CC=C

nearest known ligand 0.45

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.45
CA2 P00918 2/20 0.45
CA7 P43166 1/20 0.45
CA9 Q16790 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10633727 0.89 CA1 (0.50) CA1CA2CA7CA9
SCHEMBL811520 0.89 CA1 (0.50) CA1CA2CA7CA9
SCHEMBL10709620 0.81 CA1 (0.44) CA1CA2CA7CA9
SCHEMBL4119213 0.79 CA1 (0.43) CA1CA2CA7CA9
SCHEMBL7086367 0.78 CA1 (0.54) CA1CA2CA7CA9
SCHEMBL45005 0.75
SCHEMBL369762 0.75
SCHEMBL1656774 0.73 CA1 (0.65) CA1CA2CA7CA9
SCHEMBL6013926 0.73
SCHEMBL30534 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0657458-B1 Protein kinase C inhibitors LILLY CO ELI (US) 2001-08-22 EP disclosed
US-6057440-A AMINATION AND DEETHERIFICATION OF BISINDOLE COMPOUNDS ELI LILLY AND COMPANY (US) 2000-05-02 US disclosed
US-5843935-A Protein kinase C inhibitors ELI LILLY AND COMPANY (US) 1998-12-01 US disclosed
US-5821365-A COMPOUNDS AS ENZYME INHIBITORS FOR KINASES FORMED BY REACTION OF AMINE WITH ANHYDRIDE GROUP TO FORM INDOLMALEIMIDE MACROCYCLES ELI LILLY AND COMPANY (US) 1998-10-13 US disclosed
US-5780461-A ANTITUMOR AGENTS ELI LILLY AND COMPANY (US) 1998-07-14 US disclosed
US-5739322-A INHIBITORS OF PROTEIN KINASE C IN MAMMALS ELI LILLY AND COMPANY (US) 1998-04-14 US disclosed
US-5719175-A ALZHEIMER'S DISEASE ELI LILLY AND COMPANY (US) 1998-02-17 US disclosed
US-5698578-A BIS-INDOLEMALEIMIDE MACROCYCLE DERIVATIVES; TREATMENT OF DIABETES ELI LILLY AND COMPANY (US) 1997-12-16 US disclosed
US-5696108-A ADMINISERING TO THE MAMMAL BIS-INDOLEMALEIMIDE MACROCYCLIC DERIVATIVE AS ANTIINFLAMMATORY AGENT ELI LILLY AND COMPANY (US) 1997-12-09 US disclosed
US-5674862-A USING A BIS(INDOLEMALEIMIDE) MACROCYCLE DERIVATIVE ELI LILLY AND COMPANY (US) 1997-10-07 US disclosed
US-5624949-A Protein kinase C inhibitors ELI LILLY AND COMPANY (US) 1997-04-29 US disclosed
US-5621098-A ALKYLATION OF THE CORRESPONDING BISINDOLE COMPOUND; CYCLIZATION; PROTEIN C KINEASE INHIBITOR ELI LILLY AND COMPANY (US) 1997-04-15 US disclosed
US-5552396-A BIS-INDOLEMALEIMIDE MACROCYCLIC DERIVATIVES, ELI LILLY AND COMPANY (US) 1996-09-03 US disclosed
EP-0657458-A1 Protein kinase C inhibitors ELI LILLY AND COMPANY (US) 1995-06-14 EP disclosed