Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.39 |
| ▸ | CCR3 | P51677 | 6/20 | 0.74 |
| ▸ | ALPL | P05186 | 2/20 | 0.49 |
| ▸ | ALPI | P09923 | 2/20 | 0.49 |
| ▸ | ALPG | P10696 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | UBE2M | P61081 | 1/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1223356 | 0.92 | CCR3 (0.79) | CCR3ALPLALPIALPGTP53 | |
| SCHEMBL1223352 | 0.92 | CCR3 (0.79) | CCR3ALPLALPIALPGTP53 | |
| SCHEMBL7865818 | 0.86 | CCR3 (0.76) | CCR3ALPLALPIALPGTP53 | |
| SCHEMBL5742843 | 0.84 | CCR3 (0.67) | CCR3ALPLALPIALPGTP53 | |
| SCHEMBL5742848 | 0.84 | CCR3 (0.67) | CCR3ALPLALPIALPGTP53 | |
| SCHEMBL5854109 | 0.83 | CCR3 (0.66) | CCR3ALPLALPIALPGTP53 | |
| SCHEMBL5854102 | 0.83 | CCR3 (0.66) | CCR3ALPLALPIALPGTP53 | |
| SCHEMBL6814195 | 0.82 | CCR3 (0.65) | CCR3ALPLALPIALPGTP53 | |
| Hydrochloric Acid SCHEMBL5744002 | 0.81 | CCR3 (0.63) | CCR3MEN1KMT2AMCHR1 | |
| Hydrochloric Acid SCHEMBL5744004 | 0.81 | CCR3 (0.63) | CCR3MEN1KMT2AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131290-A1 | PIPERIDINE CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000031033-A1 | PIPERIDINE CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-02 | — | — | WO | disclosed |