Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 14/20 | 0.58 |
| ▸ | EDNRB | P24530 | 11/20 | 0.58 |
| ▸ | DHPS | P49366 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5499789 | 0.86 | EDNRA (0.63) | EDNRAEDNRBDHPS | |
| SCHEMBL5632172 | 0.85 | EDNRA (0.55) | EDNRAEDNRBDHPS | |
| SCHEMBL6780523 | 0.84 | EDNRA (0.71) | EDNRAEDNRBDHPS | |
| SCHEMBL6786069 | 0.84 | EDNRA (0.82) | EDNRAEDNRB | |
| SCHEMBL9423905 | 0.83 | EDNRA (0.70) | EDNRAEDNRBDHPS | |
| SCHEMBL5633509 | 0.82 | EDNRA (0.54) | EDNRAEDNRBDHPS | |
| SCHEMBL5208403 | 0.81 | EDNRA (0.82) | EDNRAEDNRB | |
| SCHEMBL5631703 | 0.81 | EDNRA (0.54) | EDNRAEDNRBDHPS | |
| SCHEMBL14380614 | 0.80 | EDNRA (0.51) | EDNRAEDNRBDHPS | |
| SCHEMBL5632074 | 0.80 | EDNRA (0.64) | EDNRAEDNRBDHPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137642-A1 | BIS-SULFONAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2001-10-04 | — | — | EP | disclosed |
| WO-2001017976-A1 | BIS-SULFONAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2001-03-15 | — | — | WO | disclosed |