Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 4/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627866 | 0.92 | MEN1 (0.54) | KMT2AMEN1MTORHRH4PIK3CA | |
| SCHEMBL3715528 | 0.88 | KMT2A (0.51) | KMT2AMEN1MTORHRH4PIK3CA | |
| SCHEMBL628013 | 0.86 | MEN1 (0.49) | KMT2AMEN1MTORHRH4PIK3CA | |
| SCHEMBL628391 | 0.81 | KMT2A (0.47) | KMT2AMEN1MTORHRH4PIK3CA | |
| SCHEMBL629664 | 0.78 | MAP3K12 (0.47) | KMT2AMEN1MTORHRH4PIK3CA | |
| SCHEMBL629777 | 0.77 | HRH4 (0.47) | KMT2AMEN1HRH4PIK3CAMAPT | |
| SCHEMBL628146 | 0.72 | MTOR (0.57) | KMT2AMEN1MTORPIK3CAMAPT | |
| SCHEMBL7878247 | 0.72 | MTOR (0.45) | MTORPIK3CAMAP3K12 | |
| SCHEMBL16727859 | 0.72 | MEN1 (0.41) | KMT2AMEN1MTORPIK3CAMAPT | |
| SCHEMBL15399523 | 0.72 | MAPT (0.54) | KMT2AMEN1MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120998-A1 | PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |