Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 13/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.46 |
| ▸ | MTOR | P42345 | 7/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.46 |
| ▸ | ATR | Q13535 | 7/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | FECH | P22830 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MELK | Q14680 | 1/20 | 0.38 |
| ▸ | MYLK3 | Q32MK0 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.38 |
| ▸ | TP53RK | Q96S44 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.37 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3514005 | 0.91 | ATM (0.47) | ATMPIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL3514436 | 0.86 | ATM (0.45) | ATMPIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL2067761 | 0.85 | ATM (0.52) | ATMPIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL7880213 | 0.84 | MTOR (0.45) | ATMPIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL2068935 | 0.82 | MTOR (0.55) | ATMPIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL2067482 | 0.81 | ATM (0.48) | ATMPIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL2068645 | 0.79 | ATM (0.46) | ATMPIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL7874775 | 0.79 | MTOR (0.43) | ATMPIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL7878044 | 0.79 | MTOR (0.43) | ATMPIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL3512636 | 0.79 | MTOR (0.43) | ATMPIK3CAMTORPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010139747-A1 | 1H-IMIDAZO[4, 5-c]QUINOLINONE COMPOUNDS, USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2010-12-09 | — | — | WO | disclosed |