Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 1.00 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.68 |
| ▸ | CDK2 | P24941 | 2/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.64 |
| ▸ | GSK3A | P49840 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7875828 | 0.90 | MTOR (1.00) | MTORCCNE1CDK2PIK3CAGSK3A | |
| SCHEMBL7881634 | 0.87 | MTOR (1.00) | MTORCCNE1CDK2PIK3CAGSK3A | |
| SCHEMBL7876636 | 0.85 | MTOR (1.00) | MTORCCNE1CDK2 | |
| SCHEMBL7884057 | 0.85 | MTOR (1.00) | MTORCCNE1CDK2 | |
| SCHEMBL695553 | 0.83 | MTOR (0.81) | MTORCCNE1CDK2PIK3CAGSK3A | |
| SCHEMBL12136052 | 0.83 | MTOR (0.71) | MTORPIK3CA | |
| SCHEMBL694987 | 0.83 | MTOR (0.77) | MTORCCNE1CDK2PIK3CAGSK3A | |
| SCHEMBL7879333 | 0.82 | MTOR (1.00) | MTORCCNE1CDK2PIK3CA | |
| SCHEMBL7875838 | 0.82 | MTOR (0.88) | MTORCCNE1CDK2PIK3CAGSK3A | |
| SCHEMBL7879409 | 0.81 | MTOR (1.00) | MTORCCNE1CDK2PIK3CAGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421846-B1 | 5-ALKYNYL-PYRIDINES | BOEHRINGER INGELHEIM INT (DE) | 2016-01-06 | — | — | EP | disclosed |
| US-9090564-B2 | 5-alkynyl-pyridines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH | 2015-07-28 | — | — | US | disclosed |
| US-9090564-B2 | 5-alkynyl-pyridines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH | 2015-07-28 | — | — | US | disclosed |
| US-20130196975-A1 | 5-ALKYNYL-PYRIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-08-01 | — | — | US | disclosed |
| WO-2010122069-A1 | 5-ALKYNYL-PYRIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130196975-A1 | 5-ALKYNYL-PYRIDINES | MKI67, KIT, CCNA1 | MTOR 1220/4885CCNE1 17/4885CDK2 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.