Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.36 |
| ▸ | RHEB | Q15382 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | ESRRA | P11474 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.32 |
| ▸ | SELE | P16581 | 2/20 | 0.32 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7873741 | 0.99 | HTR2A (0.36) | HTR2ASLC6A4PDE7ARHEBF2 | |
| SCHEMBL7881859 | 0.91 | RHEB (0.34) | HTR2ASLC6A4RHEBF2F10 | |
| SCHEMBL7881841 | 0.90 | RHEB (0.45) | RHEBESRRABRD4KDM4EHPGD | |
| Hydrochloric Acid SCHEMBL7880773 | 0.90 | HTR2A (0.34) | HTR2ASLC6A4RHEBF2F10 | |
| SCHEMBL7880166 | 0.89 | HTR2A (0.39) | HTR2ASLC6A4RHEBF2F10 | |
| SCHEMBL7884844 | 0.89 | RHEB (0.35) | HTR2ASLC6A4RHEBF2F10 | |
| SCHEMBL7881031 | 0.88 | RHEB (0.34) | HTR2ASLC6A4RHEBF2F10 | |
| Hydrochloric Acid SCHEMBL7881280 | 0.88 | BRD4 (0.35) | RHEBBRD4KDM4EHPGDICAM1 | |
| SCHEMBL7882020 | 0.88 | SLC6A4 (0.45) | HTR2ASLC6A4RHEBFFAR1 | |
| Hydrochloric Acid SCHEMBL7873468 | 0.88 | HTR2A (0.39) | HTR2ASLC6A4RHEBF2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |