Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CCR8 | P51685 | 7/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | TACR2 | P21452 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | TACR3 | P29371 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7873974 | 0.99 | MEN1 (0.39) | MEN1KMT2ACCR8KCNH2HRH3 | |
| SCHEMBL7873849 | 0.89 | MEN1 (0.39) | MEN1KMT2ACCR8KCNH2KDM4E | |
| SCHEMBL7877849 | 0.88 | MEN1 (0.38) | MEN1KMT2ACCR8KCNH2KDM4E | |
| SCHEMBL7877779 | 0.87 | MEN1 (0.43) | MEN1KMT2ACCR8KCNH2KDM4E | |
| SCHEMBL7879919 | 0.86 | HRH3 (0.41) | HRH3ALDH1A1 | |
| SCHEMBL7877961 | 0.86 | MEN1 (0.41) | MEN1KMT2ACCR8KCNH2KDM4E | |
| SCHEMBL7879456 | 0.86 | CHRM1 (0.37) | KCNH2 | |
| SCHEMBL7881384 | 0.85 | HRH3 (0.39) | HRH3ALDH1A1 | |
| SCHEMBL7882269 | 0.85 | KDM4E (0.40) | CCR8KCNH2KDM4EALDH1A1 | |
| SCHEMBL7879705 | 0.85 | MEN1 (0.40) | MEN1KMT2ACCR8KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |