Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CCR8 | P51685 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7873980 | 0.99 | KMT2A (0.39) | KMT2AMEN1CCR8KCNH2BRD4 | |
| SCHEMBL7873852 | 0.89 | MEN1 (0.39) | KMT2AMEN1BRD4HTR3AL3MBTL1 | |
| SCHEMBL7877852 | 0.88 | MEN1 (0.38) | KMT2AMEN1CCR8KCNH2KDM4E | |
| SCHEMBL7877785 | 0.87 | MEN1 (0.42) | KMT2AMEN1CCR8KCNH2KDM4E | |
| SCHEMBL7879922 | 0.86 | HRH3 (0.40) | KDM4EALDH1A1ACHE | |
| SCHEMBL7877963 | 0.86 | MEN1 (0.41) | KMT2AMEN1CCR8KCNH2PTPN11 | |
| SCHEMBL7879460 | 0.86 | CYP3A4 (0.37) | KCNH2BRD4CYP2D6 | |
| SCHEMBL7881391 | 0.85 | HRH3 (0.39) | KDM4EALDH1A1ACHE | |
| SCHEMBL7882273 | 0.85 | KDM4E (0.41) | CCR8KCNH2KDM4EALDH1A1 | |
| SCHEMBL7879708 | 0.84 | MEN1 (0.40) | KMT2AMEN1CCR8KCNH2HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |