Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICAM1 | P05362 | 5/20 | 0.32 |
| ▸ | SELE | P16581 | 5/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | ESRRA | P11474 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.30 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.30 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7881933 | 0.88 | PRMT5 (0.34) | ICAM1SELERAF1PPARGVCAM1 | |
| SCHEMBL7873269 | 0.87 | ESRRA (0.38) | ICAM1SELERAF1VCAM1ESRRA | |
| SCHEMBL7881882 | 0.87 | ICAM1 (0.35) | ICAM1SELERAF1VCAM1CCNC | |
| SCHEMBL7879859 | 0.87 | SMN1; SMN2 (0.38) | KDM4E | |
| SCHEMBL7881234 | 0.87 | SIRT2 (0.38) | ICAM1SELEPPARGSIRT2SIRT1 | |
| SCHEMBL7884847 | 0.87 | RHEB (0.35) | CCNCCDK8ESRRAHTR2ASLC6A4 | |
| Hydrochloric Acid SCHEMBL7873744 | 0.86 | ESRRA (0.37) | ICAM1SELERAF1VCAM1ESRRA | |
| SCHEMBL7881036 | 0.86 | ESRRA (0.35) | ICAM1SELERAF1VCAM1CCNC | |
| SCHEMBL7882394 | 0.86 | SLC6A4 (0.38) | ICAM1SELERAF1VCAM1CCNC | |
| Hydrochloric Acid SCHEMBL7877482 | 0.86 | RHEB (0.34) | CCNCCDK8ESRRAHTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |