Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.30 |
| ▸ | RHEB | Q15382 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7880183 | 0.92 | AR (0.32) | FFAR1MRGPRX4GRIN1 | |
| SCHEMBL7884361 | 0.87 | RHEB (0.33) | GRIN1EIF4A3RHEBFLT3 | |
| SCHEMBL7882315 | 0.86 | RHEB (0.32) | RHEB | |
| SCHEMBL7881416 | 0.86 | MAOB (0.36) | RHEBFLT3 | |
| SCHEMBL7877987 | 0.85 | MRGPRX4 (0.36) | MRGPRX4FLT3 | |
| SCHEMBL7882061 | 0.85 | POLB (0.35) | GRIN1EIF4A3RHEBFLT3 | |
| Hydrochloric Acid SCHEMBL7879399 | 0.85 | MAOB (0.37) | RHEBFLT3 | |
| SCHEMBL7882148 | 0.84 | KDM4E (0.38) | GRIN1RHEBFLT3 | |
| SCHEMBL7881580 | 0.84 | MEN1 (0.41) | FLT3 | |
| SCHEMBL7881260 | 0.82 | MRGPRX4 (0.37) | MRGPRX4RHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |