Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | RBP4 | P02753 | 2/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7867668 | 0.82 | HCRTR2 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL607942 | 0.81 | CNR2 (0.39) | PDE10ACNR2HCRTR1HCRTR2MAPT | |
| SCHEMBL7866579 | 0.79 | HCRTR2 (0.41) | HCRTR1HCRTR2 | |
| SCHEMBL607973 | 0.78 | PDE10A (0.41) | PDE10ACNR2HCRTR1HCRTR2MAPT | |
| SCHEMBL7864504 | 0.77 | HCRTR2 (0.54) | HCRTR1HCRTR2 | |
| SCHEMBL7870512 | 0.74 | SRC (0.37) | KMT2AMEN1 | |
| SCHEMBL16592215 | 0.71 | POLB (0.43) | KMT2AMEN1 | |
| SCHEMBL608184 | 0.68 | SCN9A (0.47) | HCRTR1HCRTR2 | |
| SCHEMBL3385637 | 0.67 | CYP3A4 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL611117 | 0.66 | HCRTR2 (0.54) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010122151-A1 | 3 -AZABICYCLO [4.1.0] HEPTANES USED AS OREXIN ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2010-10-28 | — | — | WO | disclosed |