Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PLG | P00747 | 2/20 | 0.30 |
| ▸ | PLAU | P00749 | 2/20 | 0.30 |
| ▸ | PLAT | P00750 | 2/20 | 0.30 |
| ▸ | KLK1 | P06870 | 2/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874286 | 0.87 | KDM4E (0.33) | KDM4EPOLB | |
| SCHEMBL6426421 | 0.78 | GBA1 (0.35) | KDM4E | |
| SCHEMBL7878630 | 0.78 | KDM4E (0.40) | KDM4E | |
| Hydrochloric Acid SCHEMBL6423013 | 0.78 | GBA1 (0.34) | — | |
| SCHEMBL7867229 | 0.77 | F2 (0.44) | KDM4EPOLBPLAT | |
| SCHEMBL7876212 | 0.77 | F2 (0.38) | PLAT | |
| SCHEMBL7878615 | 0.77 | F2 (0.39) | KDM4EPOLB | |
| SCHEMBL7874301 | 0.76 | F2 (0.37) | PLAT | |
| SCHEMBL7867247 | 0.76 | OPRL1 (0.34) | — | |
| SCHEMBL3240247 | 0.75 | F2 (0.46) | PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086122-A1 | PYRAZINONE PROTEASE INHIBITORS | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (US) | 2001-03-28 | — | — | EP | claimed |
| WO-1999064446-A1 | PYRAZINONE PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1999-12-16 | — | — | WO | claimed |
| EP-1086122-A1 | PYRAZINONE PROTEASE INHIBITORS | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999064446-A1 | PYRAZINONE PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1999-12-16 | — | — | WO | disclosed |