Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 20/20 | 0.87 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.87 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10236168 | 0.93 | MAPK1 (1.00) | MAPK1RPS6KA3 | |
| SCHEMBL14452909 | 0.93 | MAPK1 (1.00) | MAPK1RPS6KA3 | |
| SCHEMBL7878839 | 0.93 | MAPK1 (1.00) | MAPK1RPS6KA3 | |
| SCHEMBL10236146 | 0.92 | MAPK1 (0.87) | MAPK1RPS6KA3 | |
| SCHEMBL10236105 | 0.92 | MAPK1 (0.87) | MAPK1RPS6KA3 | |
| SCHEMBL13118891 | 0.90 | MAPK1 (0.85) | MAPK1RPS6KA3 | |
| SCHEMBL10236174 | 0.90 | MAPK1 (0.85) | MAPK1RPS6KA3 | |
| SCHEMBL13118861 | 0.90 | MAPK1 (0.84) | MAPK1RPS6KA3 | |
| SCHEMBL10236170 | 0.90 | MAPK1 (0.84) | MAPK1RPS6KA3 | |
| SCHEMBL13118820 | 0.88 | MAPK1 (0.81) | MAPK1RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |