Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 15/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 13/20 | 0.42 |
| ▸ | CDK2 | P24941 | 13/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 13/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | BMP4 | P12644 | 2/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6894225 | 0.92 | CHEK1 (0.42) | CHEK1CCNA2CDK2CCNA1ACVR1 | |
| SCHEMBL7879287 | 0.85 | CHEK1 (0.47) | CHEK1CCNA2CDK2CCNA1ACVR1 | |
| SCHEMBL6893213 | 0.81 | CHEK1 (0.48) | CHEK1CCNA2CDK2CCNA1ACVR1 | |
| SCHEMBL6894237 | 0.77 | CHEK1 (0.47) | CHEK1CCNA2CDK2CCNA1ACVR1 | |
| SCHEMBL7882498 | 0.77 | CHEK1 (0.53) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL6894250 | 0.75 | CHEK1 (0.55) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL7882759 | 0.73 | CHEK1 (0.46) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL10236515 | 0.72 | CHEK1 (0.51) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL6891716 | 0.70 | CHEK1 (0.45) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL6891599 | 0.70 | CHEK1 (0.51) | CHEK1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |