Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 8/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.41 |
| ▸ | CDK2 | P24941 | 8/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 8/20 | 0.41 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 3/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | HCK | P08631 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7880988 | 0.81 | CHEK1 (0.40) | CHEK1CCNA2CDK2CCNA1TRPV3 | |
| SCHEMBL10235313 | 0.80 | CHEK1 (0.41) | CHEK1CCNA2CDK2CCNA1NPC1 | |
| SCHEMBL10235009 | 0.80 | CHEK1 (0.40) | CHEK1CCNA2CDK2CCNA1NPC1 | |
| SCHEMBL7879289 | 0.79 | CHEK1 (0.39) | CHEK1CCNA2CDK2CCNA1TRPV3 | |
| SCHEMBL7874701 | 0.79 | CHEK1 (0.39) | CHEK1CCNA2CDK2CCNA1NPC1 | |
| SCHEMBL7879112 | 0.79 | CHEK1 (0.41) | CHEK1CCNA2CDK2CCNA1TRPV3 | |
| SCHEMBL7883682 | 0.79 | CHEK1 (0.41) | CHEK1CCNA2CDK2CCNA1NPC1 | |
| SCHEMBL10235008 | 0.78 | CHEK1 (0.39) | CHEK1CCNA2CDK2CCNA1NPC1 | |
| SCHEMBL7879813 | 0.77 | CHEK1 (0.40) | CHEK1CCNA2CDK2CCNA1SRC | |
| SCHEMBL7874811 | 0.77 | CHEK1 (0.49) | CHEK1CCNA2CDK2CCNA1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |