Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.37 |
| ▸ | CDK2 | P24941 | 6/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.37 |
| ▸ | EGFR | P00533 | 4/20 | 0.37 |
| ▸ | MTOR | P42345 | 3/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10238735 | 0.88 | CHEK1 (0.46) | PIK3CACHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL584173 | 0.87 | PIK3CA (0.41) | PIK3CAEGFRMTORFGFR2AKT1 | |
| SCHEMBL7886529 | 0.83 | NPC1 (0.37) | PIK3CAEGFRMTORPIK3CDABL1 | |
| SCHEMBL6895952 | 0.81 | CHEK1 (0.53) | PIK3CACHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL6892877 | 0.77 | CHEK1 (0.47) | PIK3CACHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL7874704 | 0.77 | CHEK1 (0.47) | PIK3CACHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL7880719 | 0.77 | CHEK1 (0.42) | PIK3CACHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL6891386 | 0.77 | CHEK1 (0.47) | PIK3CACHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL7879813 | 0.76 | CHEK1 (0.40) | PIK3CACHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL6891843 | 0.76 | CHEK1 (0.46) | PIK3CACHEK1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |