Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 14/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | RXRA | P19793 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MPC2 | O95563 | 1/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RARG | P13631 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6402925 | 0.90 | PPARG (0.66) | PPARGCYP3A4RXRAMAPTMPC2 | |
| SCHEMBL1220651 | 0.90 | PPARG (0.66) | PPARGCYP3A4RXRAMAPTMPC2 | |
| SCHEMBL1162551 | 0.90 | PPARG (0.66) | PPARGCYP3A4RXRAMAPTMPC2 | |
| Hydrochloric Acid SCHEMBL1162764 | 0.89 | PPARG (0.66) | PPARGCYP3A4RXRAMAPTMPC2 | |
| SCHEMBL7886291 | 0.78 | PPARG (0.58) | PPARGCYP3A4RXRAMAPTMPC2 | |
| SCHEMBL5810603 | 0.77 | PPARG (0.61) | PPARGCYP3A4RXRAMAPTFFAR1 | |
| SCHEMBL7875163 | 0.77 | KDM4E (0.32) | — | |
| SCHEMBL6866703 | 0.77 | PPARG (0.71) | PPARGMAPTFFAR1PPARAALDH1A1 | |
| SCHEMBL7879350 | 0.76 | PPARG (0.54) | PPARGCYP3A4RXRAMAPTMPC2 | |
| SCHEMBL7881736 | 0.76 | PPARG (0.79) | PPARGCYP3A4RXRAMAPTMPC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172089-B1 | 2,4-THIADOLIDINEDIONE INSULIN SENSITIVITY ENHANCER MIXTURE WITH ANGIOTENSIN CONVERTING ENZYME INHIBITOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-09 | — | — | US | claimed |