Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 4/20 | 0.56 |
| ▸ | BPTF | Q12830 | 5/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.41 |
| ▸ | HTR3B | O95264 | 2/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7875695 | 0.81 | SCD (0.60) | SCD | |
| SCHEMBL7884700 | 0.76 | SCD (0.52) | SCDHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL3217165 | 0.74 | SCD (0.54) | SCD | |
| SCHEMBL7880012 | 0.74 | MAPT (0.52) | SCDHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL15011912 | 0.73 | SCD (1.00) | SCD | |
| SCHEMBL3224590 | 0.72 | SCD (0.50) | SCDKDM4EALDH1A1HSD17B10CNR2 | |
| SCHEMBL3224145 | 0.72 | SCD (0.56) | SCDCYP1A2CYP3A4HTR2A | |
| SCHEMBL7880028 | 0.72 | SCD (0.48) | SCDCYP1A2CYP3A4CNR2 | |
| SCHEMBL15030147 | 0.72 | SCD (1.00) | SCD | |
| SCHEMBL3225972 | 0.72 | SCD (0.51) | SCDCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876366-B1 | ANGIOGENESIS INHIBITING PYRIDAZINAMINES | JANSSEN PHARMACEUTICA NV (BE) | 2001-07-25 | — | — | EP | disclosed |
| US-5985878-A | Angiogenesis inhibiting pyridazinamines | JANSSEN PHARMACEUTICALS, N.V. (BE) | 1999-11-16 | — | — | US | disclosed |
| EP-0876366-A2 | ANGIOGENESIS INHIBITING PYRIDAZINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997026258-A1 | ANGIOGENESIS INHIBITING PYRIDAZINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-07-24 | — | — | WO | disclosed |