Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 14/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7886989 | 1.00 | PNP (0.78) | PNP | |
| SCHEMBL7876124 | 1.00 | PNP (0.78) | PNP | |
| SCHEMBL7876095 | 0.93 | PNP (0.69) | PNP | |
| SCHEMBL7885095 | 0.89 | PNP (0.66) | PNP | |
| SCHEMBL7883558 | 0.89 | PNP (0.64) | PNP | |
| SCHEMBL7876144 | 0.89 | PNP (0.64) | PNP | |
| SCHEMBL7876147 | 0.89 | PNP (0.64) | PNP | |
| SCHEMBL7883517 | 0.89 | PNP (0.63) | PNP | |
| SCHEMBL7886996 | 0.89 | PNP (0.68) | PNP | |
| SCHEMBL7884923 | 0.89 | PNP (0.63) | PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174888-B1 | POTENT PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS; INHIBITORS OF T-CELL FORMATION, I.E., IMMUNOSUPPRESSANTS; TRANSPLANT REJECTION; AUTOIMMUNE DISEASES, E.G., RHEUMATOID DISEASES, PSORIASIS, DERMATITIS, CROHN'S DISEASE, UVEITIS; | NOVARTIS AG (CH) | 2001-01-16 | — | — | US | disclosed |
| US-6043365-A | REACTING BIARYL OR CARBOCYCLIC OR HETEROCYCLIC ISOPROPYL NITRILE DERIVATIVE WITH A LOWER ALKYL ESTER OF FORMIC ACID, CONDENSING THE INTERMEDIATE FORMED WITH AN AMINOALKYL ESTER TO OBTAIN INTERMEDIATE, CYCLIZING AND CONDENSING | NOVARTIS AG (CH) | 2000-03-28 | — | — | US | disclosed |
| EP-0986563-A1 | 2-AMINO-7-(1-SUBSTITUTED-2-HYDROXYETHYL)-3,5-DIHYDRO-PYRROLO 3,2-D]PYRIMIDIN-4-ONES | Novartis AG (CH) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998054185-A1 | 2-AMINO-7-(1-SUBSTITUTED-2-HYDROXYETHYL)-3,5-DIHYDRO-PYRROLO[3,2-D]PYRIMIDIN-4-ONES | NOVARTIS AG (CH) | 1998-12-03 | — | — | WO | disclosed |