Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 20/20 | 0.64 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12399202 | 0.91 | PDE9A (0.68) | PDE9APDE1C | |
| SCHEMBL7996231 | 0.86 | PDE9A (0.67) | PDE9APDE1C | |
| SCHEMBL12399244 | 0.86 | PDE9A (0.61) | PDE9APDE1C | |
| SCHEMBL7880529 | 0.85 | PDE9A (0.68) | PDE9APDE1C | |
| SCHEMBL7883262 | 0.85 | PDE9A (0.75) | PDE9APDE1C | |
| SCHEMBL7886919 | 0.84 | PDE9A (0.68) | PDE9APDE1C | |
| SCHEMBL7884631 | 0.83 | PDE9A (0.63) | PDE9APDE1C | |
| SCHEMBL7883272 | 0.82 | PDE9A (0.64) | PDE9APDE1C | |
| SCHEMBL7887093 | 0.82 | PDE9A (0.75) | PDE9APDE1C | |
| SCHEMBL7882616 | 0.82 | PDE9A (0.75) | PDE9APDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010112437-A1 | 1-HETEROCYCLYL-1, 5-DIHYDRO-PYRAZOLO [3, 4-D] PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-10-07 | — | — | WO | disclosed |