Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.33 |
| ▸ | RAB9A | P51151 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.31 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.31 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10239137 | 0.92 | CHEK1 (0.37) | OPRL1KMT2ARAB9AMEN1NPC1 | |
| SCHEMBL7883203 | 0.86 | CHEK1 (0.39) | KMT2ARAB9AMEN1NPC1RXFP1 | |
| SCHEMBL10235003 | 0.84 | CHEK1 (0.37) | OPRL1PIK3R1PIK3CA | |
| SCHEMBL10239214 | 0.81 | CHEK1 (0.36) | OPRL1KMT2ARAB9AMEN1NPC1 | |
| SCHEMBL10239138 | 0.81 | OPRL1 (0.31) | OPRL1 | |
| SCHEMBL7874844 | 0.80 | CHEK1 (0.40) | KMT2ARAB9AMEN1NPC1RXFP1 | |
| SCHEMBL7885854 | 0.80 | MEN1 (0.34) | OPRL1KMT2ARAB9AMEN1NPC1 | |
| SCHEMBL7884549 | 0.78 | MAP4K4 (0.38) | KMT2ARAB9AMEN1NPC1 | |
| SCHEMBL10235080 | 0.78 | CHEK1 (0.39) | KMT2ARAB9AMEN1NPC1KDM4E | |
| SCHEMBL7882746 | 0.77 | KMT2A (0.40) | KMT2ARAB9AMEN1NPC1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |