Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | STAT1 | P42224 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CDC25A | P30304 | 1/20 | 0.53 |
| ▸ | CDC25C | P30307 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.49 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.49 |
| ▸ | NQO1 | P15559 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7881982 | 0.89 | KDM4E (0.51) | KDM4EALDH1A1MAPTRAB9APOLB | |
| SCHEMBL7885079 | 0.79 | CDC25A (0.50) | KDM4EALDH1A1MAPTRAB9APOLB | |
| SCHEMBL29853686 | 0.75 | KDM4E (1.00) | KDM4EALDH1A1MAPTRAB9APOLB | |
| SCHEMBL18880260 | 0.75 | KDM4E (1.00) | KDM4EALDH1A1MAPTRAB9APOLB | |
| SCHEMBL17384081 | 0.74 | MAPT (0.80) | KDM4EALDH1A1MAPTRAB9APOLB | |
| SCHEMBL7882176 | 0.74 | AR (0.48) | KDM4EALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL31302252 | 0.74 | KDM4E (0.64) | KDM4EALDH1A1MAPTRAB9APOLB | |
| SCHEMBL31260245 | 0.73 | KDM4E (0.63) | KDM4EALDH1A1MAPTRAB9APOLB | |
| SCHEMBL9747805 | 0.72 | KDM4E (0.67) | KDM4EALDH1A1MAPTRAB9APOLB | |
| SCHEMBL12907065 | 0.72 | MAPT (1.00) | KDM4EALDH1A1MAPTRAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6169087-B1 | Modulators of protein tyrosine phosphatases (PTPases) | NOVO NORDISK A/S (DK) | 2001-01-02 | — | — | US | disclosed |
| EP-1017697-A1 | MODULES OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999015529-A1 | MODULES OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 1999-04-01 | — | — | WO | disclosed |