Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | CPT2 | P23786 | 1/20 | 0.36 |
| ▸ | CPT1A | P50416 | 1/20 | 0.36 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7881353 | 0.82 | GRM5 (0.37) | GRM5 | |
| SCHEMBL505076 | 0.79 | GRM5 (0.51) | GRM5CLK4PDE4DPDE4APDE4B | |
| SCHEMBL505271 | 0.79 | GRM5 (0.48) | GRM5CLK4PDE4DPDE4APDE4B | |
| SCHEMBL504743 | 0.75 | GRM5 (0.50) | GRM5CLK4USP30 | |
| SCHEMBL7879222 | 0.71 | KDM6B (0.35) | ADORA2AADORA1 | |
| SCHEMBL29496936 | 0.69 | CLK4 (0.66) | GRM5CLK4 | |
| SCHEMBL29472032 | 0.69 | CLK4 (0.66) | GRM5CLK4 | |
| SCHEMBL1133442 | 0.69 | CLK4 (0.66) | GRM5CLK4 | |
| SCHEMBL18411435 | 0.67 | GRM5 (0.62) | GRM5CLK4 | |
| SCHEMBL18411315 | 0.67 | GRM5 (0.62) | GRM5CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114971-A1 | COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF | SEPRACOR INC. (US) | 2010-10-07 | — | — | WO | disclosed |