Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | RYR2 | Q92736 | 13/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7878998 | 0.90 | KCNH2 (0.74) | KCNH2RYR2 | |
| SCHEMBL7882125 | 0.86 | KCNH2 (0.56) | KCNH2RYR2 | |
| SCHEMBL16381677 | 0.85 | KCNH2 (0.56) | KCNH2RYR2 | |
| SCHEMBL2600723 | 0.85 | KCNH2 (0.79) | KCNH2RYR2ALDH1A1 | |
| SCHEMBL13150270 | 0.78 | RYR2 (0.76) | KCNH2RYR2 | |
| SCHEMBL16381675 | 0.76 | KCNH2 (0.61) | KCNH2RYR2 | |
| SCHEMBL16381674 | 0.76 | KCNH2 (0.70) | KCNH2RYR2 | |
| SCHEMBL192924 | 0.75 | KCNH2 (0.98) | KCNH2RYR2 | |
| SCHEMBL13145783 | 0.75 | RYR2 (0.86) | KCNH2RYR2 | |
| Hydrochloric Acid SCHEMBL194018 | 0.75 | KCNH2 (1.00) | KCNH2RYR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120382-A1 | COMPOUNDS AND METHODS FOR MODULATING ACTIVITY OF CALCIUM RELEASE CHANNELS | STATE OF OREGON BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF PORTLAND STATE UNIVERSITY (US) | 2010-10-21 | — | — | WO | disclosed |