Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 5/20 | 0.36 |
| ▸ | BRAF | P15056 | 5/20 | 0.35 |
| ▸ | RAF1 | P04049 | 4/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.35 |
| ▸ | ARAF | P10398 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7881901 | 0.91 | RHEB (0.41) | RHEBBRAFRAF1CHEK2IDO1 | |
| SCHEMBL7882100 | 0.89 | RHEB (0.38) | RHEBARBRAFRAF1HDAC3 | |
| SCHEMBL7873348 | 0.89 | RHEB (0.38) | RHEBARBRAFRAF1HDAC3 | |
| SCHEMBL7873739 | 0.89 | RHEB (0.37) | RHEBARBRAFRAF1ARAF | |
| SCHEMBL7884287 | 0.88 | MEN1 (0.40) | RHEBBRAFRAF1HDAC3HDAC4 | |
| SCHEMBL7881493 | 0.87 | SLC6A2 (0.36) | RHEBBRAFRAF1HDAC3HDAC4 | |
| SCHEMBL7877591 | 0.86 | RAF1 (0.33) | RHEBARRAF1CHEK2 | |
| SCHEMBL7881139 | 0.85 | RAF1 (0.39) | RHEBBRAFRAF1ARAFKDR | |
| SCHEMBL7873654 | 0.85 | RHEB (0.35) | RHEBARBRAFRAF1MAPT | |
| SCHEMBL7884376 | 0.85 | RHEB (0.39) | RHEBBRAFRAF1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |