Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.62 |
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
| ▸ | CFD | P00746 | 1/20 | 0.57 |
| ▸ | MC4R | P32245 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | MC5R | P33032 | 1/20 | 0.50 |
| ▸ | MC3R | P41968 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7873338 | 0.99 | KDM4E (0.65) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| Hydrochloric Acid SCHEMBL7877487 | 0.91 | FLT3 (0.58) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| Hydrochloric Acid SCHEMBL7884870 | 0.84 | PDGFRB (0.57) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL6089719 | 0.83 | KDM4E (0.81) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL7877993 | 0.82 | FLT3 (0.48) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL7877731 | 0.82 | MEN1 (0.48) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL7877868 | 0.82 | PDGFRB (0.62) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL7878027 | 0.82 | MEN1 (0.48) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL7877889 | 0.81 | MEN1 (0.50) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| Hydrochloric Acid SCHEMBL7880952 | 0.81 | PDGFRB (0.60) | KDM4EALDH1A1CYP1A2CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0622356-B1 | Indoloylguanidine derivatives as inhibitors of sodium-hydrogen exchange | SUMITOMO PHARMA (JP) | 1998-07-01 | — | — | EP | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |
| EP-0622356-A1 | Indoloylguanidine derivatives as inhibitors of sodium-hydrogen exchange | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-11-02 | — | — | EP | disclosed |