Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 13/20 | 0.34 |
| ▸ | BCL2 | P10415 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8634815 | 0.99 | KDM4E (0.35) | KDM4EMCL1BCL2PPARANPC1 | |
| Hydrochloric Acid SCHEMBL7877315 | 0.99 | KDM4E (0.35) | KDM4EMCL1BCL2PPARANPC1 | |
| SCHEMBL7882300 | 0.94 | KDM4E (0.34) | KDM4EMCL1BCL2PPARANPC1 | |
| SCHEMBL7881142 | 0.89 | PDGFRB (0.39) | KDM4EMCL1 | |
| Hydrochloric Acid SCHEMBL8631088 | 0.88 | PDGFRB (0.39) | KDM4EMCL1 | |
| Hydrochloric Acid SCHEMBL7884347 | 0.88 | PDGFRB (0.39) | KDM4EMCL1 | |
| Hydrochloric Acid SCHEMBL7880203 | 0.87 | GRIN1 (0.34) | KDM4EMCL1BCL2DRD2DRD3 | |
| SCHEMBL7873365 | 0.87 | HDAC3 (0.42) | KDM4ENPC1RAB9AGLAGAA | |
| Hydrochloric Acid SCHEMBL8626872 | 0.87 | GRIN1 (0.34) | KDM4EMCL1BCL2DRD2DRD3 | |
| SCHEMBL7873704 | 0.87 | MAOB (0.38) | KDM4EPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0622356-B1 | Indoloylguanidine derivatives as inhibitors of sodium-hydrogen exchange | SUMITOMO PHARMA (JP) | 1998-07-01 | — | — | EP | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |
| EP-0622356-A1 | Indoloylguanidine derivatives as inhibitors of sodium-hydrogen exchange | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-11-02 | — | — | EP | disclosed |