Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | RHEB | Q15382 | 3/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.30 |
| ▸ | RAF1 | P04049 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7873184 | 0.88 | RHEB (0.38) | RHEBGRIN1EIF4A3FLT3CHEK2 | |
| SCHEMBL7873369 | 0.87 | RHEB (0.34) | RHEBNUDT1HRH4 | |
| SCHEMBL7877713 | 0.86 | RHEB (0.32) | RHEBNUDT1GRIN1HRH4EIF4A3 | |
| SCHEMBL7878080 | 0.86 | RHEB (0.31) | RHEBCHEK2LGALS8 | |
| SCHEMBL7881132 | 0.86 | RHEB (0.36) | MAPK14RHEBNOS3NOS1NOS2 | |
| SCHEMBL7884372 | 0.85 | RHEB (0.39) | RHEBTHRATHRBGRIN1EIF4A3 | |
| SCHEMBL7882126 | 0.85 | RHEB (0.32) | RHEB | |
| SCHEMBL7882347 | 0.84 | RHEB (0.39) | RHEBGRIN1HRH4EIF4A3FLT3 | |
| SCHEMBL7879697 | 0.84 | MEN1 (0.41) | MAPK14NOS3NOS1NOS2HRH4 | |
| Hydrochloric Acid SCHEMBL7884300 | 0.84 | RHEB (0.38) | RHEBTHRATHRBGRIN1EIF4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |