Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 8/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | RHEB | Q15382 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | SLC1A5 | Q15758 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7878193 | 0.92 | SLC6A4 (0.41) | SCN9AARRHEBSLC6A2SLC6A4 | |
| SCHEMBL7884854 | 0.90 | RHEB (0.37) | SCN9AARRHEBMEN1KMT2A | |
| SCHEMBL7881845 | 0.88 | MAOB (0.36) | SCN9AARRHEBMEN1KMT2A | |
| SCHEMBL7877568 | 0.87 | SLC6A4 (0.39) | SCN9ARHEBMEN1KMT2ASLC6A2 | |
| SCHEMBL7879950 | 0.85 | RHEB (0.35) | SCN9AARRHEBMEN1KMT2A | |
| SCHEMBL7878216 | 0.85 | RHEB (0.39) | ARRHEBMEN1KMT2A | |
| SCHEMBL7877872 | 0.85 | MEN1 (0.34) | SCN9ARHEBMEN1KMT2A | |
| SCHEMBL7882054 | 0.85 | SCN9A (0.37) | SCN9AMEN1KMT2AACHESLC6A2 | |
| SCHEMBL7873408 | 0.85 | SCN9A (0.38) | SCN9ARHEBMEN1KMT2ALMNA | |
| SCHEMBL7877750 | 0.84 | MEN1 (0.38) | SCN9ARHEBMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |