Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.42 |
| ▸ | CDK2 | P24941 | 5/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.40 |
| ▸ | MTOR | P42345 | 4/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7887269 | 0.93 | CHEK1 (0.42) | MAP4K4CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL10235328 | 0.92 | CHEK1 (0.42) | MAP4K4CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL6891839 | 0.90 | CHEK1 (0.43) | CHEK1CCNA2CDK2CCNA1PIK3CA | |
| SCHEMBL7885294 | 0.88 | MAP4K4 (0.43) | MAP4K4CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL10235329 | 0.85 | CHEK1 (0.42) | MAP4K4CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL7886243 | 0.85 | CDK2 (0.39) | CHEK1CCNA2CDK2CCNA1NPC1 | |
| SCHEMBL10235197 | 0.83 | CHEK1 (0.44) | CHEK1CCNA2CDK2CCNA1PIK3CA | |
| SCHEMBL7883738 | 0.80 | CHEK1 (0.47) | CHEK1CCNA2CDK2CCNA1NPC1 | |
| SCHEMBL10235183 | 0.80 | KDR (0.43) | CHEK1CCNA2CDK2CCNA1PIK3CA | |
| SCHEMBL10235325 | 0.79 | CHEK1 (0.42) | MAP4K4CHEK1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | MAP4K4 341/4885CHEK1 461/4885CCNA2 2476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.