Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874011 | 1.00 | HSD17B10 (0.36) | HSD17B10CHRM2CHRM1CHRM3HPGD | |
| SCHEMBL10188632 | 1.00 | HSD17B10 (0.36) | HSD17B10CHRM2CHRM1CHRM3HPGD | |
| SCHEMBL601143 | 0.88 | HSD17B10 (0.38) | HSD17B10CHRM2CHRM1CHRM3HPGD | |
| SCHEMBL600399 | 0.88 | HSD17B10 (0.38) | HSD17B10CHRM2CHRM1CHRM3HPGD | |
| SCHEMBL7872025 | 0.88 | HSD17B10 (0.38) | HSD17B10CHRM2CHRM1CHRM3HPGD | |
| SCHEMBL7878962 | 0.88 | HSD17B10 (0.38) | HSD17B10CHRM2CHRM1CHRM3HPGD | |
| SCHEMBL10152592 | 0.84 | HSD17B10 (0.36) | HSD17B10CHRM2CHRM1CHRM3HPGD | |
| SCHEMBL7872102 | 0.84 | HSD17B10 (0.36) | HSD17B10CHRM2CHRM1CHRM3HPGD | |
| SCHEMBL10152544 | 0.84 | HSD17B10 (0.36) | HSD17B10CHRM2CHRM1CHRM3HPGD | |
| SCHEMBL17922948 | 0.83 | HSD17B10 (0.48) | HSD17B10CHRM2CHRM1CHRM3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010124055-A1 | 2-ALKYL PIPERIDINE MGLUR5 RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-28 | — | — | WO | disclosed |