Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 11/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.45 |
| ▸ | PRKDC | P78527 | 6/20 | 0.39 |
| ▸ | ATM | Q13315 | 5/20 | 0.38 |
| ▸ | ATR | Q13535 | 3/20 | 0.37 |
| ▸ | PIK3C2A | O00443 | 2/20 | 0.37 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | LTK | P29376 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | NEK2 | P51955 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3513709 | 0.87 | MTOR (0.45) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL7875289 | 0.85 | MTOR (0.45) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL7876836 | 0.84 | MTOR (0.53) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL2069499 | 0.81 | MTOR (0.49) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL2069517 | 0.81 | MTOR (0.49) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL7875286 | 0.81 | PIK3CA (0.45) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL7870203 | 0.81 | MTOR (0.47) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL7870074 | 0.80 | PIK3CA (0.48) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL2066813 | 0.79 | MTOR (0.47) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL7878794 | 0.78 | MTOR (0.43) | MTORPIK3CAPIK3CDPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010139747-A1 | 1H-IMIDAZO[4, 5-c]QUINOLINONE COMPOUNDS, USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2010-12-09 | — | — | WO | disclosed |