Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 5/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 6/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7879689 | 0.95 | FLT3 (0.59) | FLT3PDGFRBPDGFRADRD2DRD3 | |
| SCHEMBL7952496 | 0.85 | FLT3 (0.43) | FLT3HRH3PDGFRBDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL7879744 | 0.84 | FLT3 (0.41) | FLT3PDGFRBPDGFRADRD2DRD3 | |
| Hydrochloric Acid SCHEMBL8628104 | 0.84 | FLT3 (0.41) | FLT3PDGFRBPDGFRADRD2DRD3 | |
| SCHEMBL7879728 | 0.84 | FLT3 (0.43) | FLT3PDGFRBPDGFRADRD2DRD3 | |
| SCHEMBL7873207 | 0.83 | DRD3 (0.41) | FLT3HRH3DRD2DRD3MAOB | |
| Hydrochloric Acid SCHEMBL7881414 | 0.83 | FLT3 (0.42) | FLT3PDGFRBPDGFRADRD2DRD3 | |
| SCHEMBL7884761 | 0.83 | AURKA (0.39) | FLT3HRH3PDGFRBMAOBCHEK2 | |
| SCHEMBL7881223 | 0.82 | PDGFRB (0.53) | FLT3PDGFRBPDGFRADRD2DRD3 | |
| SCHEMBL7880874 | 0.82 | RXFP1 (0.42) | FLT3HRH3CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0622356-B1 | Indoloylguanidine derivatives as inhibitors of sodium-hydrogen exchange | SUMITOMO PHARMA (JP) | 1998-07-01 | — | — | EP | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |
| EP-0622356-A1 | Indoloylguanidine derivatives as inhibitors of sodium-hydrogen exchange | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-11-02 | — | — | EP | disclosed |